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1: J Exp Med. 1998 Jun 15;187(12):2097-101.
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The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6).

Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A.

Department of Immunology and Cell Biology, Mario Negri Institute, I-20157 Milan, Italy. muziom@irfmn.mnegri.it

The human homologue of Drosophila Toll (hToll) is a recently cloned receptor of the interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of adaptive immunity. Signaling by hToll is shown to occur through sequential recruitment of the adapter molecule MyD88 and the IL-1R-associated kinase. Tumor necrosis factor receptor-activated factor 6 (TRAF6) and the nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) are both involved in subsequent steps of NF-kappaB activation. Conversely, a dominant negative version of TRAF6 failed to block hToll-induced activation of stress-activated protein kinase/c-Jun NH2-terminal kinases, thus suggesting an early divergence of the two pathways.

Publication Types:
PMID: 9625770 [PubMed - indexed for MEDLINE]

PMCID: PMC2212359