Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
Effros RB, Pawelec G.
Dept of Pathology and Laboratory Medicine, UCLA School of Medicine 90095-1732, USA. reffros@pathology.medsch.ucla.edu
Extensive in vitro research on fibroblasts has defined numerous genetic and phenotypic changes associated with replicative senescence. Identification of T-cell replicative senescence as a feature of human immunodeficiency virus (HIV) disease and ageing suggests this phenomenon merits more careful consideration by immunologists, especially with regard to chronic infection, memory and adoptive immunotherapy.
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PMID: 9293162 [PubMed - indexed for MEDLINE]