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1: Endocrinology. 2004 Dec;145(12):5448-51. Epub 2004 Aug 26.
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Minireview: RET: normal and abnormal functions.

Santoro M, Melillo RM, Carlomagno F, Vecchio G, Fusco A.

Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c/o Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Naples, Italy. masantor@unina.it

The RET gene encodes a single-pass transmembrane receptor tyrosine kinase. RET is the oncogene that causes papillary thyroid carcinoma and medullary thyroid carcinoma. The latter may arise as a component of multiple endocrine neoplasia type 2 syndromes; germline mutations in RET are responsible for multiple endocrine neoplasia type 2 inheritance. In this report we review data on the mechanisms leading to RET oncogenic conversion and on RET targeting as a strategy in thyroid cancer treatment.

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PMID: 15331579 [PubMed - indexed for MEDLINE]