Melatonin Origin And Function (Dov Henis, 03 February 2009)
Beyond Darwin 200<br>Melatonin Switches On Mostly Intercell Maintenance<br>Wake up. <br>Re-think-plan-do-assess Epigenetics, Sleep And Melatonin works. <br><br><br>A. "Epigenetics reveals unexpected, and some identical, results"<br>http://www.sciencenews.org/view/generic/id/40060/title/Epigenetics_reveals_unexpected%2C_and_some_identical%2C_results<br>One study finds tissue-specific methylation signatures in the genome; another a similarity between identical twins in DNA’s chemical tagging.<br><br>I humbly suggest : Re-think-plan-do-assess Epigenetics Works, founded on scientific conception that genes and genomes are organisms. <br><br><br>B. "Sleep, Melatonin, Cancers And Beyond Darwin...
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Bedside Evaluation endothelial Function in Hypertensives. (Sergio Stagnaro, 18 August 2008)
I find the paper fascinating and interesting. In addition, Authors’s data agree with my clinical results. The endothelium is notoriously the main regulator of vascular wall homeostasis. Physiologically, endothelial cells maintain a relaxed vascular tone, physiological chaotic movements of both macro- and micro-vessels (2, 3), and low levels of oxidative stress (eNO is a radical!), in part by releasing mediators, including NO, prostacyclin (PGI2), and endothelin (ET-1), and controlling local angiotensin II activity. In addition, the endothelium actively regulates vascular permeability to plasma constituents, platelet and leukocyte adhesion and aggregation, and thrombosis. This state of balanced endothelial regulation of blood vessel function is, however, altered by a number of...
read full comment
Augmenting immune system activiti in aging is really complex. (Sergio Stagnaro, 17 March 2008)
Editors,This paper is really interesting, paying attention to the most outstanding problems of vaccination in aging people. However, NOT all aged individuals are equal, in the sense that, e.g., melatonine deficiency as well as Co Q10 deficiency syndrome is present in some but not all (1-5).Melatonine, among a lot of other actions, stimulates immunesystem, and Ubidecarenone is a potente scavenger of free radicals, as Melatonine.In my opinion, bedside biophysical-semeiotic diagnosis of Co Q10 deficincy syndrome, I described earlier (1-4), could be very helpful in risk stratification to predict absence of benefical effect after vaccination in Older Adults. In fact, I have demonstrated that doctors can clinically recognize subjects involved by Ubidecarenone deficiency, even initial and...
read full comment
Biophysical-Semeiotic Consitutions play a pivotal role also in age-related diseases. (Sergio Stagnaro, 12 June 2007)
Sirs,we must agree with the statement that biophysical-semeiotic consitutions are as important in all other life-periods as in ageing (1-7). For instance, “Inflammation is not per se a negative phenomenon: it is the response of the immune system to the invasion of viruses or bacteria and other pathogens”. But, not all aged individuals have identical immune system, we can nowadays evaluate at the bedside in precise, rapid, and relaible way (1, 2). In addition, without Oncological Terrain and Oncological Real Risk, localized since birth in a well-defined biological system, oncogenesis is not possible (3-6, 8). Furthermore, aged subjects my be involved by so-called “senile” type 2 diabetes if they are positive SINCE BIRTH for both diabetic “and”...
read full comment
Assessing NK cell compartment in individuals with CAD Inherited Real Risk (Sergio Stagnaro, 14 May 2007)
Sirs, to certain extent, I agree with the authors of this intriguing article on the importance of studying NK compartment in CAD patients. However, I add someting more: A) we must know that it really exsist the untill now overloked CAD Inherited Real Risk, recognized bedside since birth with a sthetoscope (www.semeioticabiofisica.it). It's characterized by "coronary microcirculatory remodelling", based on altered compliance of coronary arterioles, according to Hammersen, and particularly on newborn-pathological, type I, subtype b), Endoarteriolar Blocking Devices, I discovered (1-3); B)we have to utilize in CAD Primary Prevention the study of NK compartment also in CAD primary prevention, at the condition that we recognize "clinically" those who are at coronary Real Risk, conditio sine...
read full comment
We have a lot to learn about 'diseases of the aging' (Trevor Marshall, 19 December 2006)
In 2004 we described how the chronic inflammatory disease, sarcoidosis, is caused by a life-long accumulation of intra-phagocytic bacterial pathogens[1]. We recently published an update[2], reporting that many chronic inflammatory diseases result from a similar pathogenesis. Our Phase 2 clinical trial has already been demonstrating recovery from some of the diseases of aging, particularly arthritis, osteopenia, and even diabetes[3].Interestingly, those patients who have recovered from terminal inflammatory conditions, such as sarcoidosis and rheumatoid arthritis, report that recovery feels like "being 20 years younger." We are also observing that the body has an amazing ability to regenerate after inflammatory damage which is currently considered to be 'permanent' (eg, fibrosis and...
read full comment
Immunoceutic effect of medicinal mushroom extracts (Tang Ch'ang, 15 May 2006)
I am approaching 80 years of age, living with manageable chronic ailments - Diabetes type 2, high blood pressure, gout but all under control by medication. I am also taking supplements such as Vitamins, Grape Seed Extract and walking exercise to maintain fitness. My life style is quite acceptable. Would I also benefit if I took immune-boosting mushroom extracts as an aid to my weakening immnue system?
read full comment
Study the immune system in ageing and disease (Gerard Ligthart, 21 January 2006)
Yes dear colleagues! A warm applause for your article. That is exactly what I was trying to say in my contribution to the discussion in MAD in 2001 (Mech. Ageing Development 2001; 122, 136-140).Now we are making progress in our concepts of the role of the immune system in ageing.We, the scientific community interested in Immunology & aging, should help you forward.I work as a geriatrician in 'pure' practice.We have access to large numbers of geriatric patients of all levels of frailty. If that could be of any use, let me know, we might also be able to get some funding for a good reseach project.But in any case: I am very happy with your article as it helps us forward and it stimulates further thinking! With kind regards, Prof.dr. Gerard Ligthart, MD, PhD, geriatricianDepartment of...
read full comment
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Latest comments
Melatonin Origin And Function (Dov Henis, 03 February 2009)
Beyond Darwin 200<br>Melatonin Switches On Mostly Intercell Maintenance<br>Wake up. <br>Re-think-plan-do-assess Epigenetics, Sleep And Melatonin works. <br><br><br>A. "Epigenetics reveals unexpected, and some identical, results"<br>http://www.sciencenews.org/view/generic/id/40060/title/Epigenetics_reveals_unexpected%2C_and_some_identical%2C_results<br>One study finds tissue-specific methylation signatures in the genome; another a similarity between identical twins in DNA’s chemical tagging.<br><br>I humbly suggest : Re-think-plan-do-assess Epigenetics Works, founded on scientific conception that genes and genomes are organisms. <br><br><br>B. "Sleep, Melatonin, Cancers And Beyond Darwin... read full comment
Comment on: Srinivasan et al. Immunity & Ageing, 2:17
Bedside Evaluation endothelial Function in Hypertensives. (Sergio Stagnaro, 18 August 2008)
I find the paper fascinating and interesting. In addition, Authors’s data agree with my clinical results. The endothelium is notoriously the main regulator of vascular wall homeostasis. Physiologically, endothelial cells maintain a relaxed vascular tone, physiological chaotic movements of both macro- and micro-vessels (2, 3), and low levels of oxidative stress (eNO is a radical!), in part by releasing mediators, including NO, prostacyclin (PGI2), and endothelin (ET-1), and controlling local angiotensin II activity. In addition, the endothelium actively regulates vascular permeability to plasma constituents, platelet and leukocyte adhesion and aggregation, and thrombosis. This state of balanced endothelial regulation of blood vessel function is, however, altered by a number of... read full comment
Comment on: Colomba et al. Immunity & Ageing, 5:4
Augmenting immune system activiti in aging is really complex. (Sergio Stagnaro, 17 March 2008)
Editors,This paper is really interesting, paying attention to the most outstanding problems of vaccination in aging people. However, NOT all aged individuals are equal, in the sense that, e.g., melatonine deficiency as well as Co Q10 deficiency syndrome is present in some but not all (1-5).Melatonine, among a lot of other actions, stimulates immunesystem, and Ubidecarenone is a potente scavenger of free radicals, as Melatonine.In my opinion, bedside biophysical-semeiotic diagnosis of Co Q10 deficincy syndrome, I described earlier (1-4), could be very helpful in risk stratification to predict absence of benefical effect after vaccination in Older Adults. In fact, I have demonstrated that doctors can clinically recognize subjects involved by Ubidecarenone deficiency, even initial and... read full comment
Comment on: Aspinall et al. Immunity & Ageing, 4:9
Biophysical-Semeiotic Consitutions play a pivotal role also in age-related diseases. (Sergio Stagnaro, 12 June 2007)
Sirs,we must agree with the statement that biophysical-semeiotic consitutions are as important in all other life-periods as in ageing (1-7). For instance, “Inflammation is not per se a negative phenomenon: it is the response of the immune system to the invasion of viruses or bacteria and other pathogens”. But, not all aged individuals have identical immune system, we can nowadays evaluate at the bedside in precise, rapid, and relaible way (1, 2). In addition, without Oncological Terrain and Oncological Real Risk, localized since birth in a well-defined biological system, oncogenesis is not possible (3-6, 8). Furthermore, aged subjects my be involved by so-called “senile” type 2 diabetes if they are positive SINCE BIRTH for both diabetic “and”... read full comment
Comment on: Licastro et al. Immunity & Ageing, 2:8
Assessing NK cell compartment in individuals with CAD Inherited Real Risk (Sergio Stagnaro, 14 May 2007)
Sirs, to certain extent, I agree with the authors of this intriguing article on the importance of studying NK compartment in CAD patients. However, I add someting more: A) we must know that it really exsist the untill now overloked CAD Inherited Real Risk, recognized bedside since birth with a sthetoscope (www.semeioticabiofisica.it). It's characterized by "coronary microcirculatory remodelling", based on altered compliance of coronary arterioles, according to Hammersen, and particularly on newborn-pathological, type I, subtype b), Endoarteriolar Blocking Devices, I discovered (1-3); B)we have to utilize in CAD Primary Prevention the study of NK compartment also in CAD primary prevention, at the condition that we recognize "clinically" those who are at coronary Real Risk, conditio sine... read full comment
Comment on: Hak et al. Immunity & Ageing, 4:3
We have a lot to learn about 'diseases of the aging' (Trevor Marshall, 19 December 2006)
In 2004 we described how the chronic inflammatory disease, sarcoidosis, is caused by a life-long accumulation of intra-phagocytic bacterial pathogens[1]. We recently published an update[2], reporting that many chronic inflammatory diseases result from a similar pathogenesis. Our Phase 2 clinical trial has already been demonstrating recovery from some of the diseases of aging, particularly arthritis, osteopenia, and even diabetes[3].Interestingly, those patients who have recovered from terminal inflammatory conditions, such as sarcoidosis and rheumatoid arthritis, report that recovery feels like "being 20 years younger." We are also observing that the body has an amazing ability to regenerate after inflammatory damage which is currently considered to be 'permanent' (eg, fibrosis and... read full comment
Comment on: Giunta Immunity & Ageing, 3:12
Immunoceutic effect of medicinal mushroom extracts (Tang Ch'ang, 15 May 2006)
I am approaching 80 years of age, living with manageable chronic ailments - Diabetes type 2, high blood pressure, gout but all under control by medication. I am also taking supplements such as Vitamins, Grape Seed Extract and walking exercise to maintain fitness. My life style is quite acceptable. Would I also benefit if I took immune-boosting mushroom extracts as an aid to my weakening immnue system? read full comment
Comment on: Castle et al. Immunity & Ageing, 3:1
Study the immune system in ageing and disease (Gerard Ligthart, 21 January 2006)
Yes dear colleagues! A warm applause for your article. That is exactly what I was trying to say in my contribution to the discussion in MAD in 2001 (Mech. Ageing Development 2001; 122, 136-140).Now we are making progress in our concepts of the role of the immune system in ageing.We, the scientific community interested in Immunology & aging, should help you forward.I work as a geriatrician in 'pure' practice.We have access to large numbers of geriatric patients of all levels of frailty. If that could be of any use, let me know, we might also be able to get some funding for a good reseach project.But in any case: I am very happy with your article as it helps us forward and it stimulates further thinking! With kind regards, Prof.dr. Gerard Ligthart, MD, PhD, geriatricianDepartment of... read full comment
Comment on: Castle et al. Immunity & Ageing, 3:1