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Open Access Highly Accessed Review

CMV and Immunosenescence: from basics to clinics

Rafael Solana1*, Raquel Tarazona2, Allison E Aiello3, Arne N Akbar4, Victor Appay5, Mark Beswick6, Jos A Bosch307, Carmen Campos1, Sara Cantisán1, Luka Cicin-Sain8, Evelyna Derhovanessian9, Sara Ferrando-Martínez10, Daniela Frasca11, Tamas Fulöp12, Sheila Govind13, Beatrix Grubeck-Loebenstein14, Ann Hill15, Mikko Hurme16, Florian Kern17, Anis Larbi18, Miguel López-Botet19, Andrea B Maier20, Janet E McElhaney21, Paul Moss6, Elissaveta Naumova22, Janko Nikolich-Zugich23, Alejandra Pera1, Jerrald L Rector24, Natalie Riddell4, Beatriz Sanchez-Correa2, Paolo Sansoni25, Delphine Sauce5, Rene van Lier26, George C Wang27, Mark R Wills28, Maciej Zieliński29 and Graham Pawelec9

Author Affiliations

1 Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Reina Sofia University Hospital-University of Cordoba, Cordoba, Spain

2 Immunology Unit, Department of Physiology, University of Extremadura, Caceres, Spain

3 University of Michigan, Department of Epidemiology, Center for Social Epidemiology and Population Health, Ann Arbor, Michigan, USA

4 Division of Infection and Immunity, University College London, London, UK

5 Infections and Immunity, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France

6 School of Cancer Sciences, University of Birmingham, Birmingham, UK

7 University of Amsterdam, Amsterdam, The Netherlands

8 Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

9 Department of Internal Medicine II, Center for Medical Research, University of Tübingen, Tübingen, Germany

10 Laboratory of Molecular Immune-Biology, Hospital General Universitario Gregorio Marañón, Madrid and Laboratory of Immunovirology; Infectious Diseases Service, IBiS, Seville, Spain

11 Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA

12 Research Center on Aging, Sherbrooke, Canada

13 Regenerative Medicine Group, Cranfield Health, Cranfield University, Cranfield, UK

14 Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria

15 Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, USA

16 University of Tampere, Medical School, Tampere, Finland

17 Brighton and Sussex Medical School, Brighton, UK

18 Singapore Immunology Network, Singapore, Singapore

19 IMIM (Hospital del Mar Research Institute), Univ. Pompeu Fabra, Barcelona, Spain

20 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

21 University of British Columbia, Vancouver, Canada

22 Department of Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria

23 Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, USA

24 University of Birmingham, Birmingham, UK

25 Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy

26 Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands

27 Division of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

28 University of Cambridge Department of Medicine Addenbrookes Hospital, Cambridge, UK

29 Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland

30 Mannheim Institute of Public Health, Social and Preventive Medicine (MIPH), University of Heidelberg, Mannheim Medical Faculty, Mannheim, Germany

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Immunity & Ageing 2012, 9:23  doi:10.1186/1742-4933-9-23

Published: 31 October 2012

Abstract

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates “immunosenescence”. This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.