Short report
Age-related decrease of miRNA-92a levels in human CD8+ T-cells correlates with a reduction of naïve T lymphocytes
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* Corresponding author: Kazuma Ohyashiki ohyashik@rr.iij4u.or.jp
1 Department of Hematology, Tokyo Medical University, Tokyo, Japan
2 Institute of Medical Science, Tokyo Medical University, Tokyo, Japan
Immunity & Ageing 2011, 8:11 doi:10.1186/1742-4933-8-11
Published: 15 November 2011Additional files
Additional file 1:
Correlation between age and percentage of lymphocyte fraction or miR-92a expression level.
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Additional file 2:
Correlation between miR-92a and percentage of lymphocyte fraction.
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Additional file 3:
Correlation between T-lymphocyte subset and age. An increase in the ratios of central memory to naïve CD8+ (P = 0.0663) (A), effector memory to naïve CD8+ (P = 0.0527) (C), and central memory to naïve CD4+ (P = 0.0096) (E) with age is notable. The miR-92a level in CD8+ T-cells is negatively correlated with the ratio of central memory to naïve CD8+ cells (P = 0.0016) or effector memory/naïve CD8+ cells (P = 0.0073). By contrast, the miR-92a level in CD4+ T-cells is not correlated with the ratio of central memory to naïve CD4+ cells (P = 0.0925) (F).
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