Short report

Characterization of leukotrienes in a pilot study of older asthma subjects

Sharmilee M Nyenhuis^1,2 , Elizabeth A Schwantes¹ and Sameer K Mathur¹

¹  Department of Medicine, Section of Allergy, Pulmonary and Critical Care, University of Wisconsin, Madison, WI, USA

²  Department of Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois-Chicago, Chicago, IL, USA

author email corresponding author email

Immunity & Ageing 2010, 7:8doi:10.1186/1742-4933-7-8

Published:	5 July 2010

First paragraph (this article has no abstract)

Asthma is a chronic inflammatory disorder of the lower airway that results in mucus secretion, airway edema and reversible airway obstruction [1]. These characteristic features lead to the clinical symptoms of asthma, which include recurrent episodes of wheezing, breathlessness, chest tightness and coughing [2]. The pathophysiology of asthma is not fully elucidated but the current paradigm involves multiple cell types (ie. eosinophils, neutrophils, mast cells, T-cells) and their mediators.