Short report
Characterization of leukotrienes in a pilot study of older asthma subjects
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* Corresponding author: Sameer K Mathur sm4@medicine.wisc.edu
1 Department of Medicine, Section of Allergy, Pulmonary and Critical Care, University of Wisconsin, Madison, WI, USA
2 Department of Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois-Chicago, Chicago, IL, USA
Immunity & Ageing 2010, 7:8 doi:10.1186/1742-4933-7-8
Published: 5 July 2010First paragraph (this article has no abstract)
Asthma is a chronic inflammatory disorder of the lower airway that results in mucus secretion, airway edema and reversible airway obstruction [1]. These characteristic features lead to the clinical symptoms of asthma, which include recurrent episodes of wheezing, breathlessness, chest tightness and coughing [2]. The pathophysiology of asthma is not fully elucidated but the current paradigm involves multiple cell types (ie. eosinophils, neutrophils, mast cells, T-cells) and their mediators.