Immunity & Ageing

unofficial impact factor 3.00

Open Access Review

BELFAST nonagenarians: nature or nurture? Immunological, cardiovascular and genetic factors

I M Rea

Author Affiliations

Department of Geriatric Medicine, School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland

Immunity & Ageing 2010, 7:6 doi:10.1186/1742-4933-7-6

Published: 27 May 2010

Abstract

Nonagenarians are the fastest growing sector of populations across Western European and the developed world. They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.

The Belfast Longevity Group enlisted the help of 500 community-living, mobile, mentally competent, 'elite' nonagenarians, as part of an ongoing study of ageing. We assessed some immunological, cardiovascular, nutritional and genetic factors and some aspects of their interaction in this group of 'oldest old'.

Here we present some of the evidence related to genetic and nutritional factors which seem to be important for good quality ageing in nonagenarians from the Belfast Elderly Longitudinal Free-living Ageing STudy (BELFAST).