Table 5 |
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|
Blood mononuclear cell functions at basal state (T0) and after supplementation with 13-cis-retinoic acid (T1) |
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|
Parameters |
Incubation |
Young adults |
Elderly |
|||
|
Time |
T0 |
T1 |
T0 |
T1 |
ANOVA |
|
|
|
||||||
|
IL2 production |
48 h |
0.57 ± 0.24 |
0.75 ± 0.22 |
1.95 ± 0.75 |
0.77 ± 0.18 |
- |
|
|
||||||
|
sIl-2R production |
48 h |
168 ± 24 |
186 ± 25 |
174 ± 27 |
201 ± 28 |
- |
|
|
||||||
|
Membrane expression of CD25 (%) |
48 h |
27.5 ± 3.7 |
27.1 ± 2.8 |
21.3 ± 2.9 |
20.9 ± 2.4 |
- |
|
96 h |
28 ± 2.9 |
34.4 ± 3.1 |
32.7 ± 3.9 |
32.4 ± 3.9 |
- |
|
|
|
||||||
|
Number of CD25 receptors per cell |
48 h |
1214 ± 51 |
1366 ± 75 |
1157 ± 46 |
1262 ± 68 |
- |
|
96 h |
874 ± 12 |
952 ± 22 |
1064 ± 67 |
1089 ± 27 |
A |
|
|
|
||||||
|
X ± SEM; n = 20 subjects per group. Two-way repeated-measures ANOVA was performed to discriminate among the effects of age (A; p < 0.05), nutritional treatment (N; p < 0.05) and their interaction (I; p < 0.05). Il-2 and sIl-2R productions were determined in culture media and expressed in fmol/106 cells As no significant interaction was found, comparison of marginal means was carried out, which indicated a significant effect of age on number of CD25 receptors per cell (96 h) (young: 914.03 ± 14.16 vs elderly: 1077.24 ± 34.21) |
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|
Minet-Quinard et al. Immunity & Ageing 2010 7:10 doi:10.1186/1742-4933-7-10 |
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