Richard Aspinall*, Giuseppe Del Giudice, Rita B Effros, Beatrix Grubeck-Loebenstein and Suryaprakash Sambhara
Corresponding author: Richard Aspinall email@example.com
Immunity & Ageing 2007, 4:9 doi:10.1186/1742-4933-4-9
(2008-03-17 06:37) Biophysical Semeiotics Research Laboratory
This paper is really interesting, paying attention to the most outstanding problems
of vaccination in aging people. However, NOT all aged individuals are equal, in the
sense that, e.g., melatonine deficiency as well as Co Q10 deficiency syndrome is
present in some but not all (1-5).Melatonine, among a lot of other actions, stimulates
immunesystem, and Ubidecarenone is a potente scavenger of free radicals, as Melatonine.
In my opinion, bedside biophysical-semeiotic diagnosis of Co Q10 deficincy syndrome,
I described earlier (1-4), could be very helpful in risk stratification to predict
absence of benefical effect after vaccination in Older Adults. In fact, I have demonstrated
that doctors can clinically recognize subjects involved by Ubidecarenone deficiency,
even initial and symptomless, causing damage of tissues due to the increase levels
of free radicals (1-4). Moreover, in my 52-year-long clinical experience, such as
diagnosis, made for the first time clinically, proved to be really efficaious and
reliable in avoiding dangerous administration of statine to individuals without clinical
sintomatology, but involved by ubidecarenone deficiency, notoriously worsened by anti-cholesterolemic
drugs. In addition, physicians are able to recognize since birth whatever inherited
biophysical-semeiotic Real Risk, including oincological and diabetic one (5, 6, 7),
based on microvascular remodelling, characterized by newborn-pathological, type I,
subtype a), oncological, and b) aspecific Endoarteriolar Blocking Devices, which
predispose to the related disorders. Finally, only individuals with inherited cerebral
biophysical-semeiotic Real Risk may be involved by functional decline, particularly
in presence of
Co Q10 deficincy syndrome.
1)Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia ipolipidemmizante
diagnosticata con la Percussione Ascoltata. Settimana Italiana di Dietologia, 9-13
Aprile 1991, Merano. Atti, pg. 65. Epat. 37, 17, 1990.
2)Stagnaro-Neri M., Stagnaro S., Acidi grassi W-3, scavengers dei radicali liberi
e attivatori del ciclo Q della sintesi del Co Q10. Gazz. Med. It. – Arch. Sc.
Med. 151, 341, 1992.
3) Stagnaro-Neri M., Stagnaro S., Auscultatory Percussion Coenzyme Q deficiency Syndrome.
VI Int. Symp., Biomedical and clinical aspects of Coenzyme Q. Rome, January 22.24,
1990,Chairmen K. Folkers, G.L. Littarru, T. Yamagani, Abs., pg. 105.
4) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-ascoltatoria da carenza
di Co Q10. Medic. Geriatr. XXIV, 239.
5) Stagnaro S. Newborn-pathological Endoarteriolar Blocking Devices in Diabetic
and Dislipidaemic Constitution and Diabetes Primary Prevention. The Lancet. March
06 2007. http://www.thelancet.com/journals/lancet/article/PIIS0140673607603316/comments?totalcomments=1
6) Stagnaro S. Bedside diagnosis of osteoporotic constitution, real risk of inheriting
ostoporosis, and finally osteoporosis. Theoretical Biology and Medical Modelling
21 June 2007. http://www.tbiomed.com/content/4/1/23/comments#285569
7) Stagnaro S. New bedside way in reducing mortality in diabetic men and women.
Ann. Int. Med. http://www.annals.org/cgi/eletters/0000605-200708070-00167v1
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