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Challenges for vaccination in the elderly

Richard Aspinall*, Giuseppe Del Giudice, Rita B Effros, Beatrix Grubeck-Loebenstein and Suryaprakash Sambhara

Immunity & Ageing 2007, 4:9  doi:10.1186/1742-4933-4-9

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Augmenting immune system activiti in aging is really complex.

Sergio Stagnaro   (2008-03-17 06:37)  Biophysical Semeiotics Research Laboratory email


This paper is really interesting, paying attention to the most outstanding problems of vaccination in aging people. However, NOT all aged individuals are equal, in the sense that, e.g., melatonine deficiency as well as Co Q10 deficiency syndrome is present in some but not all (1-5).Melatonine, among a lot of other actions, stimulates immunesystem, and Ubidecarenone is a potente scavenger of free radicals, as Melatonine.

In my opinion, bedside biophysical-semeiotic diagnosis of Co Q10 deficincy syndrome, I described earlier (1-4), could be very helpful in risk stratification to predict absence of benefical effect after vaccination in Older Adults. In fact, I have demonstrated that doctors can clinically recognize subjects involved by Ubidecarenone deficiency, even initial and symptomless, causing damage of tissues due to the increase levels of free radicals (1-4). Moreover, in my 52-year-long clinical experience, such as diagnosis, made for the first time clinically, proved to be really efficaious and reliable in avoiding dangerous administration of statine to individuals without clinical sintomatology, but involved by ubidecarenone deficiency, notoriously worsened by anti-cholesterolemic drugs. In addition, physicians are able to recognize since birth whatever inherited biophysical-semeiotic Real Risk, including oincological and diabetic one (5, 6, 7), based on microvascular remodelling, characterized by newborn-pathological, type I, subtype a), oncological, and b) aspecific Endoarteriolar Blocking Devices, which predispose to the related disorders. Finally, only individuals with inherited cerebral biophysical-semeiotic Real Risk may be involved by functional decline, particularly in presence of

Co Q10 deficincy syndrome.


1)Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia ipolipidemmizante diagnosticata con la Percussione Ascoltata. Settimana Italiana di Dietologia, 9-13 Aprile 1991, Merano. Atti, pg. 65. Epat. 37, 17, 1990.

2)Stagnaro-Neri M., Stagnaro S., Acidi grassi W-3, scavengers dei radicali liberi e attivatori del ciclo Q della sintesi del Co Q10. Gazz. Med. It. – Arch. Sc. Med. 151, 341, 1992.

3) Stagnaro-Neri M., Stagnaro S., Auscultatory Percussion Coenzyme Q deficiency Syndrome. VI Int. Symp., Biomedical and clinical aspects of Coenzyme Q. Rome, January 22.24, 1990,Chairmen K. Folkers, G.L. Littarru, T. Yamagani, Abs., pg. 105.

4) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-ascoltatoria da carenza di Co Q10. Medic. Geriatr. XXIV, 239.

5) Stagnaro S. Newborn-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. The Lancet. March 06 2007.

6) Stagnaro S. Bedside diagnosis of osteoporotic constitution, real risk of inheriting ostoporosis, and finally osteoporosis. Theoretical Biology and Medical Modelling 21 June 2007.

7) Stagnaro S. New bedside way in reducing mortality in diabetic men and women. Ann. Int. Med.

Competing interests

None declared


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