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Open Access Highly Accessed Review

Pathophysiology of ageing, longevity and age related diseases

Alexander Bürkle1, Graziella Caselli2, Claudio Franceschi3, Erminia Mariani45, Paolo Sansoni6, Angela Santoni7, Giancarlo Vecchio8, Jacek M Witkowski9 and Calogero Caruso10*

Author Affiliations

1 Department of Biology, Box X911, University of Konstanz, Konstanz, Germany

2 Department of Demographic Sciences, University "La Sapienza" of Rome, Rome, Italy

3 Department of Experimental Pathology and CIG – Interdepartmental Center "L. Galvani", University of Bologna, Italy

4 Immunology and Genetics Laboratory, Institute Codivilla-Putti, Bologna, Italy

5 Department of Internal Medicine and Gastroenterology of University of Bologna, Bologna, Italy

6 Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy

7 Department of Experimental Medicine, University "La Sapienza" of Rome, Rome, Italy

8 Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, Naples, Italy

9 Department of Pathophysiology, Medical University of Gdansk, Gdansk, Poland

10 Immunosenescence Unit, Department of Pathobiology and Biomedical Methodologies, University of Palermo, Palermo, Italy

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Immunity & Ageing 2007, 4:4  doi:10.1186/1742-4933-4-4

Published: 2 August 2007

Abstract

On April 18, 2007 an international meeting on Pathophysiology of Ageing, Longevity and Age-Related Diseases was held in Palermo, Italy. Several interesting topics on Cancer, Immunosenescence, Age-related inflammatory diseases and longevity were discussed. In this report we summarize the most important issues. However, ageing must be considered an unavoidable end point of the life history of each individual, nevertheless the increasing knowledge on ageing mechanisms, allows envisaging many different strategies to cope with, and delay it. So, a better understanding of pathophysiology of ageing and age-related disease is essential for giving everybody a reasonable chance for living a long and enjoyable final part of the life.