|
Characteristics of the immune risk phenotype |
| CD4:8 ratio < 1 |
| poor T cell proliferative responses to mitogens |
| increased CD8+CD28-negative and CD8+CD57+ cells |
| low B cells count |
| CMV-seropositivity |
| clonal expansions of CD8 cells carrying receptors for CMV |
| high proportion of dysfunctional cells amongst the CMV-specific CD8 cells |
Vasto et al. Immunity & Ageing 2007 4:2 doi:10.1186/1742-4933-4-2 |