A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis

doi:10.1186/1742-4933-3-5

Immunity & Ageing

Volume 3

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Gupta S
Agrawal A
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Su H
Gollapudi S

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Su H
Gollapudi S
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Review

A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis

Sudhir Gupta , Anshu Agrawal , Sudhanshu Agrawal , Houfen Su and Sastry Gollapudi

Laboratories of Cellular and Molecular Immunology, Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA

author email corresponding author email

Immunity & Ageing 2006, 3:5doi:10.1186/1742-4933-3-5


Published:	19 May 2006

Abstract

Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunodeficiency and paradoxical increased inflammation associated with human aging. In particular, a role of apoptotic cells in failure to generate anti-inflammatory responses and directly activating inflammatory responses will be discussed.